METFORMIN
METFORMIN

METFORMIN

Clinician-prescribed metabolic support

Longevity & VitalityOral tabletMenOff-label use
Starting at$25Metformin XR 500 — $25/month
Select treatment

1 Month Supply

Select duration
Metformin — 1 Month Supply$25
About

What is Metformin?

Metformin is an oral medication FDA-approved for the management of type 2 diabetes. When prescribed off-label by a US-licensed clinician, it may be used to support insulin sensitivity and metabolic health. Off-label use is not FDA-approved for this purpose; risks, benefits, and alternatives will be reviewed by your clinician. Individual results vary.

Snapshot

The essentials

Time to results
Week 1–2
Improved blood sugar and appetite control; energy and fat loss from week 4+.
Physician reviewed
US-licensed
Prescribed and titrated by a licensed clinician after online evaluation.
Monitoring
B12 annually
Ongoing check-ins with kidney function and vitamin B12 review.
Best for
Metabolic health
Insulin sensitivity, body composition, and longevity-focused care.
How it works

Your protocol, step by step

1

AMPK ACTIVATION

Metformin activates AMP-activated protein kinase (AMPK), a key energy sensor that promotes fat oxidation, glucose uptake, and mitochondrial biogenesis—mimicking the effects of fasting.

2

INSULIN SENSITIVITY & GLYCEMIC CONTROL

It lowers circulating insulin and glucose levels, helping reduce systemic inflammation and oxidative stress, two hallmarks of aging and metabolic decline.

3

mTOR PATHWAY MODULATION

Research suggests Metformin may modulate the mTOR pathway and support autophagy, a cellular cleanup and repair process being studied in longevity research.

Benefits

What patients look for

Enhances insulin sensitivity and stabilizes blood sugar
May reduce visceral fat and improve body composition
Supports mitochondrial function and metabolic flexibility
May reduce the risk of age-related diseases (heart disease, cancer, cognitive decline)
Activates cellular repair pathways (AMPK, autophagy)
What's included

Included in your plan

Supports insulin sensitivity
Clinician-guided titration
Once-daily oral tablet
Ongoing metabolic monitoring
FAQ

Questions, answered

Start with 500mg once daily, gradually titrate up to 1000–2000mg daily if tolerated. Week 1–2: Improved blood sugar and appetite control. Week 4+: Enhanced energy, fat loss, cognitive clarity. Metabolic benefits are most commonly observed with consistent, long-term use under clinician supervision. Best when combined with fasting, low-glycemic nutrition, and exercise. Missed dose? Skip and resume at the next scheduled time—do not double up.
Related

More in Longevity & Vitality

B12
B12

B12

Endurance and focus, naturally.

Cyanocobalamin Vitamin B12 — injection

Starting at$251 Month Supply: $25
View treatment
NAD+ Injectable
Peptides

NAD+ Injectable

Enhance energy levels, mental clarity & mood by supporting DNA health

NAD+ — injectable

Starting at$299$169.00 for a 1 month supply
View treatment
NAD+ Nasal Spray
Peptides

NAD+ Nasal Spray

Boost your energy with NAD+

NAD+ — nasal spray

Starting at$149$149.00 for a 1 month supply
View treatment

Prescription products require a medical evaluation by a licensed provider. Treatment is only prescribed when clinically appropriate. Compounded medications are not FDA-approved products. Prices are as listed and may vary by dose, supply length and pharmacy.