Doxycycline (Doxy-PEP)
DOXY-PEP

Doxycycline (Doxy-PEP)

Take control after contact.

Sexual HealthDoxycycline Hyclate 100mg — oral tablets in a bottleMenWomen
Starting at$95$95 per month
About

About Doxy-PEP

Doxycycline is a tetracycline-class antibiotic used as post-exposure prophylaxis (PEP) against sexually transmitted infections. Known as Doxy-PEP, this therapy involves taking doxycycline after condomless sex to reduce the risk of acquiring chlamydia, syphilis, and gonorrhea. It is taken within 72 hours of sexual exposure.

Snapshot

The essentials

Dose
200mg
Usually two 100mg tablets, taken within 72 hours of condomless sex.
Quantity
60 tablets
Oral tablets in a bottle.
Coverage
Bacterial STIs
Does not protect against viral STIs such as HIV, herpes or HPV.
Suggested retail
$95 / month
Per the medication reference document.
How it works

Your protocol, step by step

1

POST-EXPOSURE ANTIBIOTIC ACTION

When taken after sex, doxycycline kills or suppresses bacteria before they can multiply and cause infection — particularly effective against chlamydia and syphilis, and partially effective against gonorrhea.

2

PREVENTION AT THE MICROBIAL LEVEL

The drug accumulates in tissue and mucosal surfaces, helping protect the urethra, rectum, and pharynx during early post-exposure windows.

3

SIMPLE, TARGETED STRATEGY

Doxy-PEP is taken only after potential exposure, not daily, making it easier for some individuals to adhere to than daily PrEP-style regimens.

Benefits

What patients look for

Reduces risk of bacterial STIs by 50–80% in high-risk groups
Simple, convenient, non-daily dosing
Proven effective in real-world and clinical studies
May reduce STI-related complications and transmission
Can be combined with HIV PrEP for full-spectrum protection
FAQ

Questions, answered

Take one 200mg dose within 72 hours of condomless sex, ideally under guidance of a provider familiar with sexual health and STI risk. Continue regular STI screening every 3 months.
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